Boc-甘氨酸叔-丁基酯合成路线 （共 14 条）
反应条件
1: N-Boc-glycine t-butyl ester With N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in tetrahydrofuran T=-78°C; Metallation; 2: 4-bromo-but-1-ene in tetrahydrofuran T=-78 - 20°C; Alkylation; 7.5 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
Tetrahedron, 1999 , vol. 55, # 1 p. 63 - 88
反应条件
1.1: n-BuLi; HMPA / tetrahydrofuran / -78 °C 1.2: 86 percent / tetrahydrofuran / 7.5 h / -78 - 20 °C 2.1: 91 percent / m-CPBA / CH2Cl2 / 17 h / 20 °C View Scheme
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
Tetrahedron, 1999 , vol. 55, # 1 p. 63 - 88
反应条件
1.1: n-BuLi; HMPA / tetrahydrofuran / -78 °C 1.2: 86 percent / tetrahydrofuran / 7.5 h / -78 - 20 °C 2.1: borane-THF complex / tetrahydrofuran / 14 h / 0 - 20 °C 2.2: 45 percent / NaOH; H2O2 / tetrahydrofuran; H2O / 0.5 h / 0 °C View Scheme
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
Tetrahedron, 1999 , vol. 55, # 1 p. 63 - 88
反应条件
zinc dibromide in dichloromethane T=20°C; 24 h;
参考文献
Kaul, Ramesh; Brouillette, Yann; Sajjadi, Zohreh; Hansford, Karl A.; Lubell, William D.
Journal of Organic Chemistry, 2004 , vol. 69, # 18 p. 6131 - 6133
