1: 98 percent / propionic acid / 24 h / Heating 2: 91 percent / Al2O3 / benzene / 11 h / Heating 3: 60 percent / LiAl(t-BuO)H3 / tetrahydrofuran / 3 h / -50 °C 4: 93 percent / activated MnO2 / petroleum ether / 2 h / 25 °C 5: 1.) Mg / 1.) THF, 2 h, 2.) THF, -15 deg C, 2 h 6: 54 percent / Me3SiCl, NaI / acetonitrile / 3 h / 25 °C View Scheme

1: 98 percent / propionic acid / 24 h / Heating 2: 91 percent / Al2O3 / benzene / 11 h / Heating 3: 60 percent / LiAl(t-BuO)H3 / tetrahydrofuran / 3 h / -50 °C 4: 93 percent / activated MnO2 / petroleum ether / 2 h / 25 °C 5: 1.) Mg / 1.) THF, 2 h, 2.) THF, -15 deg C, 2 h 6: 54 percent / Me3SiCl, NaI / acetonitrile / 3 h / 25 °C View Scheme

Multi-step reaction with 3 steps 1: 98 percent / propionic acid / 24 h / Heating2: 91 percent / Al2O3 / benzene / 11 h / Heating3: 60 percent / LiAl(t-BuO)H3 / tetrahydrofuran / 3 h / -50 °C  

Multi-step reaction with 4 steps 1: 98 percent / propionic acid / 24 h / Heating2: 91 percent / Al2O3 / benzene / 11 h / Heating3: 60 percent / LiAl(t-BuO)H3 / tetrahydrofuran / 3 h / -50 °C4: 93 percent / activated MnO2 / petroleum ether / 2 h / 25 °C  

Multi-step reaction with 5 steps 1: 98 percent / propionic acid / 24 h / Heating2: 91 percent / Al2O3 / benzene / 11 h / Heating3: 60 percent / LiAl(t-BuO)H3 / tetrahydrofuran / 3 h / -50 °C4: 93 percent / activated MnO2 / petroleum ether / 2 h / 25 °C5: 1.) Mg / 1.) THF, 2 h, 2.) THF, -15 deg C, 2 h