N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
反应条件
1: N,O-dimethyl-hydroxylamine With trimethylaluminum in toluene
T=-5 - 0°C;
2: methyl β-phenylpropionate in toluene
T=0 - 20°C;
参考文献
Trost, Barry M.; Machacek, Michelle R.; Faulk, Brian D.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6745 - 6754
反应条件
1: 3-phenyl-propionaldehyde With 1-hydroxy-pyrrolidine-2,5-dione; oxygen; [Co(O2CCH3)2]*4H2O in acetonitrile
T=20°C; P=760.051 Torr; 24 h; Molecular sieve;
2: N,O-dimethyl-hydroxylamine in acetonitrile
T=20°C; Molecular sieveInert atmosphere;
参考文献
Yao, Haoyi; Yamamoto, Kana
Chemistry - An Asian Journal, 2012 , vol. 7, # 7 p. 1542 - 1545
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
参考文献
Sumitomo Chemical Company, Limited
Patent: US4123256 A1, 1978 ;
反应条件
TEA; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
hydrogenchloride; sodium hydrogencarbonate; sodium nitrite
1.) water, 0 deg C, 0.5 h, 2.) water, 0.5 h; Multistep reaction;
参考文献
Wilman, Derry E. V.; Cox, Peter J.; Goddard, Phyllis M.; Hart, Leigh I.; Merai, Kanti; Newell, David R.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 870 - 874
参考文献
Sumitomo Chemical Company, Limited
Patent: US4129436 A1, 1978 ;
反应条件
triethylamine
Acylation;
参考文献
Barrett, Anthony G. M.; Cramp, Susan M.; Roberts, Richard S.; Zecri, Frederic J.
Organic Letters, 2000 , vol. 2, # 3 p. 261 - 264
反应条件
pyridine in chloroform
参考文献
Davis, Lindsey O.; Tobey, Suzanne L.
Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6078 - 6081
