N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
反应条件
1: 3-carboxyazetidine-1-carboxylic acid tert-butyl ester With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole in tetrahydrofuran
T=20°C; 0.5 h;
2: N,O-dimethyl-hydroxylamine in tetrahydrofuran
T=20°C; 15 h;
参考文献
GAWECO, Anderson; WALKER, John; MONAHAN, Joseph, B.; CUBBAGE, Jerry, W.; CARROLL, Jeffery
Patent: WO2012/9649 A1, 2012 ;
Location in patent: Page/Page column 92-93 ;
反应条件
iso-propylmagnesium bromide in tetrahydrofuran
T=0 - 20°C; 0.166667 h;
参考文献
DOOSAN CORPORATION; IMAGENE CO., LTD.
Patent: WO2006/4359 A1, 2006 ;
Location in patent: Page/Page column 11; 12; 15; 16; 18; 20; 22 ;
WO 2006/004359 A1
反应条件
iso-propylmagnesium bromide in tetrahydrofuran
T=0°C;
参考文献
Ha, Hyun-Joon; Hong, Myeng Chan; Ko, Seung Whan; Kim, Yong Woo; Lee, Won Koo; Park, Jungchan
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1880 - 1883
反应条件
iso-propylmagnesium bromide in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Singh, Alok; Ha, Hyun-Joon; Park, Jungchan; Kim, Jun Hee; Lee, Won Koo
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6174 - 6181
反应条件
water; sodium acetate
参考文献
Boese; Jones; Major
Journal of the American Chemical Society, 1931 , vol. 53, p. 3530,3534
参考文献
Boese; Jones; Major
Journal of the American Chemical Society, 1931 , vol. 53, p. 3530,3534
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; Inert atmosphere;
参考文献
AMPLA PHARMACEUTICALS INC.; HAUSKE, James, R.
Patent: WO2010/120889 A1, 2010 ;
Location in patent: Page/Page column 56; 60 ;
WO 2010/120889 A1
反应条件
1: 5-Bromo-2-chloro-3-pyridinecarboxylic acid With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 1 h;
2: N,O-dimethyl-hydroxylamine in dichloromethane
T=20°C;
参考文献
PFIZER INC.
Patent: WO2009/16460 A2, 2009 ;
Location in patent: Page/Page column 102-104 ;
WO 2009/016460 A2
反应条件
1: 2,6-dichloropyridine-4-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 2 h;
2: N,O-dimethyl-hydroxylamine With triethylamine
T=0 - 20°C; 2 h; Neat (no solvent);
参考文献
Eberle, Martin; Stierli, Daniel; Pillonel, Christian; Ziegler, Hugo
Patent: US2003/236256 A1, 2003 ;
Location in patent: Page 39 ;
反应条件
triethylamine; 1,1'-carbonyldiimidazole
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
