N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
参考文献
Major,R.T.; Ohly,K.W.
J. Med. Pharm. Chem., 1961 , vol. 4, # 2 p. 317 - 326
反应条件
4-(N,N-dimethlyamino)pyridine; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine in dichloromethane
T=20°C; 2 h;
参考文献
MERCK and CO., INC.
Patent: WO2008/124143 A1, 2008 ;
Location in patent: Page/Page column 23 ;
WO 2008/124143 A1
参考文献
Major,R.T.; Ohly,K.W.
J. Med. Pharm. Chem., 1961 , vol. 4, # 2 p. 317 - 326
参考文献
Major,R.T.; Ohly,K.W.
J. Med. Pharm. Chem., 1961 , vol. 4, # 2 p. 317 - 326
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Zhao, Zhong; Araldi, Gian Luca; Xiao, Yufang; Reddy, Adulla P.; Liao, Yihua; Karra, Srinivasa; Brugger, Nadia; Fischer, David; Palmer, Elizabeth
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6572 - 6575
反应条件
1: [3H]-Nicotinic acid With thionyl chloride
1 h; Reflux;
2: N,O-dimethyl-hydroxylamine With triethylamine in dichloromethane
T=20°C; 1.5 h;
参考文献
NOVARTIS AG
Patent: WO2009/156462 A2, 2009 ;
Location in patent: Page/Page column 78-79 ;
反应条件
pyridine in dichloromethane
T=0 - 20°C; 1.16667 h; Inert atmosphere;
参考文献
Chanthamath, Soda; Takaki, Suguru; Shibatomi, Kazutaka; Iwasa, Seiji
Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5818 - 5821
Angew. Chem., 2013 , vol. 125, # 22 p. 5930 - 5933,4
反应条件
1,1'-carbonyldiimidazole
参考文献
Schiaffo, Charles E.; Rottman, Matthias; Wittlin, Sergio; Dussault, Patrick H.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 4 p. 316 - 319
参考文献
Aventis Pharmaceuticals Inc.
Patent: US6407119 B1, 2002 ;
Location in patent: Page column 3 ;
参考文献
Major,R.T.; Ohly,K.W.
J. Med. Pharm. Chem., 1961 , vol. 4, # 2 p. 317 - 326
