N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
GENELABS TECHNOLOGIES, INC.
Patent: WO2006/76529 A1, 2006 ;
Location in patent: Page/Page column 158 ;
反应条件
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine in dichloromethane
参考文献
Capela, Rita; Oliveira, Rudi; Goncalves, Lidia M.; Domingos, Ana; Gut, Jiri; Rosenthal, Philip J.; Lopes, Francisca; Moreira, Rui
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 12 p. 3229 - 3232
反应条件
zirconium tetrachloride in dichloromethane; acetonitrile T=23°C; 1 h;
参考文献
Dineen, Thomas A.; Zajac, Matthew A.; Myers, Andrew G.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 16406 - 16409
反应条件
in dichloromethane T=0 - 20°C; 5.25 h;
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
in dichloromethane T=20°C; 14 h; Inert atmosphere;
参考文献
Jeon, Kyu Ok; Rayabarapu, Dinesh; Rolfe, Alan; Volp, Kelly; Omar, Iman; Hanson, Paul R.
Tetrahedron, 2009 , vol. 65, # 26 p. 4992 - 5000
反应条件
triethylamine; 1,1'-carbonyldiimidazole
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
反应条件
1: With triethylamine T=0°C; 2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine
参考文献
Falkiewicz; Wisniowski; Kolodziejczyk; Wisniewski
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1393 - 1397
反应条件
in dichloromethane T=0 - 20°C; 6.25 h;
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether in toluene T=105°C; P=3000.3 Torr; 12 h;
参考文献
Dang, Tuan T.; Zhu, Yinghuai; Ngiam, Joyce S. Y.; Ghosh, Subhash C.; Chen, Anqi; Seayad, Abdul M.
ACS Catalysis, 2013 , vol. 3, # 6 p. 1406 - 1410
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
