N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
参考文献
Angewandte Chemie - International Edition, , vol. 46, # 18 p. 3242 - 3244
反应条件
triethylamine; HATU in dichloromethane T=20°C; 12 h; Inert atmosphere;
参考文献
ENVIVO PHARMACEUTICALS, INC.
Patent: WO2009/158393 A1, 2009 ;
Location in patent: Page/Page column 117 ;
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
AMPLA PHARMACEUTICALS INC.; HAUSKE, James, R.
Patent: WO2010/120889 A1, 2010 ;
Location in patent: Page/Page column 45; 50 ;
WO 2010/120889 A1
反应条件
triethylamine; 1,1'-carbonyldiimidazole
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
参考文献
Jones; Major
Journal of the American Chemical Society, 1927 , vol. 49, p. 1539
Journal of the American Chemical Society, 1928 , vol. 50, p. 3388
反应条件
4-methyl-morpholine in dichloromethane
参考文献
PROXIMAGEN LIMITED; EVANS, David; CARLEY, Allison; STEWART, Alison; HIGGINBOTTOM, Michael; SAVORY, Edward; SIMPSON, Iain; NILSSON, Marianne; HARALDSSON, Martin; NORDLING, Erik; KOOLMEISTER, Tobias
Patent: WO2013/37411 A1, 2013 ;
Location in patent: Page/Page column 31 ;
反应条件
1: 4-methyl-benzoic acid With N-ethyl-N,N-diisopropylamine; [bis(2-methoxyethyl)amino]-sulfur trifluoride in N,N-dimethyl-formamide T=0°C; 0.25 h; 2: N,O-dimethyl-hydroxylamine in N,N-dimethyl-formamide T=0 - 20°C; 4 h; Further stages.;
参考文献
Tunoori, Ashok Rao; White, Jonathan M.; Georg, Gunda I.
Organic Letters, 2000 , vol. 2, # 25 p. 4091 - 4093
反应条件
pyridine in chloroform
参考文献
Turnbull, Kenneth; Sun, Congcong; Krein, Douglas M.
Tetrahedron Letters, 1998 , vol. 39, # 12 p. 1509 - 1512
反应条件
in tetrahydrofuran T=-78°C; 3 h;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
1,1'-carbonyldiimidazole
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
