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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1117681-39-6
合成路线
(共 4 条)
1117681-39-6
→
反应条件
65875-05-0
5,6,7,7a,8,9,10,11-八氢-4H-苯并[ef]庚搭烯
反应条件
1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 3 h 2: sodium hydroxide / methanol; water / 3 h / 20 °C 3: polyphosphoric acid / 4 h / 110 °C 4: trifluoroacetic acid; triethylsilane / 60 °C View Scheme
参考文献
Amano, Yohei; Noguchi, Masayuki; Nakagomi, Madoka; Muratake, Hideaki; Fukasawa, Hiroshi; Shudo, Koichi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4342 - 4350
1117681-39-6
→
反应条件
65875-07-2
1-(5,6,7,7a,8,9,10,11-八氢-4H-苯并[ef]-2-庚搭烯)乙酮
反应条件
1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 3 h 2: sodium hydroxide / methanol; water / 3 h / 20 °C 3: polyphosphoric acid / 4 h / 110 °C 4: trifluoroacetic acid; triethylsilane / 60 °C 5: AlCl3, aluminium chloride View Scheme
参考文献
Amano, Yohei; Noguchi, Masayuki; Nakagomi, Madoka; Muratake, Hideaki; Fukasawa, Hiroshi; Shudo, Koichi
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4342 - 4350
867-13-0
膦酰乙酸三乙酯
+
1117681-38-5
→
反应条件
1117681-39-6
反应条件
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in benzene T=0°C; Stage #2: (6,7,8,9-tetrahydro-5H-5-benzocycloheptenyl)acetaldehyde in benzene T=0°C; Reflux; Show Experimental Procedure
参考文献
Research Foundation Itsuu Laboratory Patent: EP2189443 A1, 2010 ; Location in patent: Page/Page column 36 ;
1117681-39-6
→
反应条件
1117681-40-9
反应条件
With hydrogen; palladium 10 on activated carbon in ethyl acetate 3 h; Show Experimental Procedure
参考文献
Research Foundation Itsuu Laboratory Patent: EP2189443 A1, 2010 ; Location in patent: Page/Page column 36 ;