3-(二甲基氨基)-1-(2-吡嗪)-2-丙烯-1-酮合成路线 （共 4 条）
反应条件
in anhydrous xylene T=140°C; 20 h; Inert atmosphereSchlenk technique;
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
反应条件
sodium hydroxide in isopropyl alcohol
20 h; Heating / reflux;
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1533304 A1, 2005 ;
Location in patent: Page/Page column 16 ;
EP 1533304 A1
反应条件
1: sodium hydroxide / butan-1-ol / 12 h / |Inert atmosphere; |Schlenk technique; |Reflux
2: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / 1,4-dioxane / 20 h / 20 - 100 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
反应条件
1: sodium hydroxide / butan-1-ol / 12 h / |Inert atmosphere; |Schlenk technique; |Reflux
2: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / 1,4-dioxane / 20 h / 20 - 100 °C / |Inert atmosphere; |Schlenk technique
3: hydrazine hydrate; anhydrous iron chloride; carbon / water / 80 °C / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
