(3aS,4S,6aR)-N-(2-氨基乙基)六氢-2-氧代-1H-噻吩并[3,4-d]咪唑-4-戊酰胺合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Yamada, Michio; Harada, Kenji; Maeda, Yutaka; Hasegawa, Tadashi
New Journal of Chemistry, 2013 , vol. 37, # 11 p. 3762 - 3769
反应条件
in methanol T=60°C; 48 h;
参考文献
Tao, Lei; Geng, Jin; Chen, Gaojian; Xu, Yingjian; Ladmiral, Vincent; Mantovani, Giuseppe; Haddleton, David. M.
Chemical Communications, 2007 , # 33 p. 3441 - 3443
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Bioorganic and medicinal chemistry, , vol. 11, # 2 p. 235 - 249
反应条件
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 5 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 31 p. 8124 - 8128
Angew. Chem., , vol. 125, # 31 p. 8282 - 8286
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 14 p. 4077 - 4079
反应条件
1.1: TBTU; HOBt / dimethylformamide / 0.33 h / 20 °C 1.2: triethylamine / dimethylformamide / 3 h / 20 °C 2.1: aq. HCl / ethyl acetate View Scheme
参考文献
Journal of the American Chemical Society, , vol. 124, # 30 p. 8768 - 8769
