6-甲氧基-3-硝基吡啶-2-乙腈合成路线 （共 8 条）
反应条件
potassium tert-butylate in tetrahydrofuran T=-20°C; 35 h; Inert atmosphere;
参考文献
Jeanty, Matthieu; Suzenet, Franck; Guillaumet, Gerald
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7390 - 7393
反应条件
sodium hydride in dimethyl sulfoxide T=20 - 25°C; 5 h;
参考文献
Jonczyk, Andrzej; Kowalkowska, Anna
Synthesis, 2002 , # 5 p. 674 - 680
反应条件
hydrogen; triethylamine; 10 palladium on active carbon in ethanol; triethylamine P=2280 Torr; 2 h; Ambient temperature;
参考文献
Makosza, Mieczyslaw; Danikiewicz, Witold; Wojciechowski, Krzysztof
Liebigs Annalen der Chemie, 1988 , p. 203 - 208
反应条件
potassium carbonate in acetonitrile T=20°C; 3.5 h;
参考文献
Jeanty, Matthieu; Suzenet, Franck; Guillaumet, Gerald
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7390 - 7393
反应条件
1: 1.) PPh3, DEAD / 1.) THF, 0 deg C, 5 min, 2.) THF, 0 deg C, 34 min 2: 16 percent / H2 / 10percent Pd/C / butan-1-ol View Scheme
参考文献
Macor, John E.; Wehner, Jennifer M.
Tetrahedron Letters, 1991 , vol. 32, # 49 p. 7195 - 7198
反应条件
1: 81 percent / hydrogen / 10 percent palladium on charcoal / ethanol / 5 h / 2327.17 Torr / Ambient temperature 2: 32 percent / 33 percent acetic acid / H2O / 4 h / Heating View Scheme
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2327.17 Torr; 5 h; Ambient temperature;
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
1: 71 percent / hydrogen / palladium on charcoal / ethanol / 5 h / 20 °C / 2327.17 Torr
2: 99 percent / sodium hydroxide / benzyltriethylammonium chloride / CH2Cl2 / 2.25 h / 0 - 20 °C
View Scheme
参考文献
Larraya, Carlos; Guillard, Jerome; Renard, Pierre; Audinot, Valerie; Boutin, Jean A.; Delagrange, Philippe; Bennejean, Caroline; Viaud-Massuard, Marie-Claude
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 6 p. 515 - 526
