(2R,3R,4S,5R)-2-[6-[12-[[9-[(2R,3R,4S,5R)-3,4-二羟基-5-(羟基甲基)四氢呋喃-2-基]嘌呤-6-基]氨基]十二烷基氨基]嘌呤-9-基]-5-(羟基甲基)四氢呋喃-3,4-二醇合成路线 （共 10 条）
反应条件
1: 80 percent / 0.25 h / 150 - 160 °C
2: 74.4 percent / CBr4/PPh3 / acetonitrile / 1 h / Ambient temperature
3: 90.6 percent / toluene / 15 h / Heating
4: 1) t-BuOK / 1) -78 deg C, THF, 2a) -78 deg C, 7h, 2b) -78 deg C to RT, overnight
5: 39 percent / hydrazine hydrate / ethanol
6: 20 percent / pyridine / dimethylaminopyridine / Ambient temperature
7: 64 percent / methanolic ammonia
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: 74.4 percent / CBr4/PPh3 / acetonitrile / 1 h / Ambient temperature
2: 90.6 percent / toluene / 15 h / Heating
3: 1) t-BuOK / 1) -78 deg C, THF, 2a) -78 deg C, 7h, 2b) -78 deg C to RT, overnight
4: 39 percent / hydrazine hydrate / ethanol
5: 20 percent / pyridine / dimethylaminopyridine / Ambient temperature
6: 64 percent / methanolic ammonia
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: dimethylaminopyridine, pyridine / Ambient temperature
2: methanolic ammonia / 16 h / Ambient temperature
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: 90.6 percent / toluene / 15 h / Heating
2: 1) t-BuOK / 1) -78 deg C, THF, 2a) -78 deg C, 7h, 2b) -78 deg C to RT, overnight
3: 39 percent / hydrazine hydrate / ethanol
4: 20 percent / pyridine / dimethylaminopyridine / Ambient temperature
5: 64 percent / methanolic ammonia
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: 1) t-BuOK / 1) -78 deg C, THF, 2a) -78 deg C, 7h, 2b) -78 deg C to RT, overnight
2: 39 percent / hydrazine hydrate / ethanol
3: 20 percent / pyridine / dimethylaminopyridine / Ambient temperature
4: 64 percent / methanolic ammonia
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: 1) t-BuOK / 1) -78 deg C, THF, 2a) -78 deg C, 7h, 2b) -78 deg C to RT, overnight
2: 39 percent / hydrazine hydrate / ethanol
3: 20 percent / pyridine / dimethylaminopyridine / Ambient temperature
4: 64 percent / methanolic ammonia
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
water; hydrogen cation
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
ammonia
16 h; Ambient temperature; Yield given;
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
反应条件
1: dimethylaminopyridine, pyridine / Ambient temperature
2: methanolic ammonia / 16 h / Ambient temperature
View Scheme
参考文献
Agathocleous, Demetrios C.; Bulman Page, Philip C.; Cosstick, Richard; Galpin, Ian J.; McLennan, Alexander G.; Prescott, Mark
Tetrahedron, 1990 , vol. 46, # 6 p. 2047 - 2058
