1-(2-氟吡啶-4-基)乙酮合成路线 （共 9 条）
反应条件
1: in tetrahydrofuran; diethyl ether T=0°C; 2: With ammonium chloride in tetrahydrofuran; diethyl ether; water Saturated solution;
参考文献
WO2009/114552 A1, ;
Page/Page column 156 ;
反应条件
1: in tetrahydrofuran; diethyl ether T=0 - 5°C; 2 h; 2: With water; ammonium chloride in tetrahydrofuran; diethyl ether
参考文献
WO2005/84439 A1, ;
Page/Page column 33 ;
WO 2005/084439 A1
反应条件
1: in diethyl ether; hexane T=25°C; Cooling with ice; 2: With water; citric acid in diethyl ether; hexane T=0°C;
参考文献
WO2010/25451 A2, ;
Page/Page column 50-51 ;
反应条件
manganese(IV) oxide in toluene 12 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 57, # 2 p. 565 - 573
反应条件
fluorine in 1,2,2-trifluoro-trichloroethane T=0°C;
参考文献
Tetrahedron Letters, , vol. 28, # 3 p. 255 - 258
反应条件
1: 1) LDA, 2) bromine / 1) THF, -75 deg C, 4 h, 2) -75 deg C, 0.5 h 2: 1) n-BuLi, TMEDA / 1) Et2O, -60 deg C, 0.5 h, 2) Et2O, -75 deg C, 2 h 3: 85 percent / MnO2 / toluene / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 2 p. 565 - 573
反应条件
1: 1) n-BuLi, TMEDA / 1) Et2O, -60 deg C, 0.5 h, 2) Et2O, -75 deg C, 2 h 2: 85 percent / MnO2 / toluene / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 2 p. 565 - 573
反应条件
1.1: cesium fluoride / sulfolane / 20 h / 100 °C 2.1: hexane; diethyl ether / 25 °C / Cooling with ice 2.2: 0 °C View Scheme
反应条件
1: 65 percent / PTSA / toluene / 24 h / Heating 2: 1) LDA, 2) iodine / 1) THF, -75 deg C, 4 h, 2) THF, -75 deg C, 3 h View Scheme
参考文献
Marsais; Pineau; Nivolliers; Mallet; Turck; Godard; Queguiner
Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 565 - 573
