(E,E)-2,4-己二烯二酸二甲酯合成路线 （共 18 条）
反应条件
1: ammonia / ethanol; water / 336 h / 20 °C 2: hydrogen; ammonia / Cr2Cu2O5 / tetrahydrofuran / 2 h / 250 °C / 89469 Torr View Scheme
反应条件
1: ammonia / ethanol; water / 336 h / 20 °C 2: hydrogen; ammonia / Cr2Cu2O5 / tetrahydrofuran / 5 h / 250 °C / 85331.7 Torr View Scheme
反应条件
1: ammonia / ethanol; water / 336 h / 20 °C 2: trichlorophosphate / Reflux 3: hydrogen; ammonia / Raney nickel / water; tetrahydrofuran / 3 h / 110 °C / 18100.7 Torr / Parr reactor View Scheme
反应条件
1: m-xylene / 48 h / 151 - 168 °C / 13446.2 Torr 2: 5 palladium on Al2O3 / 7.5 h / 300 - 325 °C / Inert atmosphere View Scheme
反应条件
hydrogenchloride; zinc in acetic acid
参考文献
Oehme, G.; Pracejus, H.
Journal fuer Praktische Chemie (Leipzig), 1980 , vol. 322, # 5 p. 798 - 808
反应条件
1: ammonia / ethanol; water / 336 h / 20 °C 2: trichlorophosphate / Reflux 3: hydrogen; ammonia / Raney nickel / water; tetrahydrofuran / 3 h / 110 °C / 18100.7 Torr / Parr reactor View Scheme
参考文献
AMYRIS, INC.; BUI, Vu; FROST, John W.
Patent: WO2012/141993 A1, 2012 ;
反应条件
hydrogenchloride
1.) MeOH, THF, r.t., 38 h; 2.) reflux, 1.5 h; Multistep reaction;
参考文献
Amemiya; Kojima; Okano; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 873 - 875
反应条件
(i) Mor, (ii) (acid hydrolysis); Multistep reaction;
参考文献
Zhurin,R.B.; Vainer,V.B.
Zhurnal Organicheskoi Khimii, 1972 , vol. 8, # 5 p. 959 - 961,964 - 966
