反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
2: Grubb's 2nd generation catalyst / 1,2-dichloro-ethane / 2 h / Reflux
3: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 20 °C
View Scheme
参考文献
Kusuma, Bhaskar Reddy; Peterson, Laura B.; Zhao, Huiping; Vielhauer, George; Holzbeierlein, Jeffrey; Blagg, Brian S. J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6234 - 6253
