2-(3-溴-2,2-二甲基丙基)异吲哚啉-1,3-二酮合成路线 （共 3 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 25°C; 12 h; Inert atmosphere;
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
Location in patent: Page/Page column 251 ;
反应条件
in N,N-dimethyl-formamide T=90°C; 10 h;
参考文献
Wu, Yong; Shi, Chen; Sun, Xiaowei; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4238 - 4249
反应条件
1.1: hydrogen bromide / 1 h / 110 °C 1.2: 11 h / 110 °C 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere View Scheme
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
