反应条件
1: 75.8 percent / bis(trimethylsilyl)acetamide / CH2Cl2 / 1.) -10 deg C, 1 h, 2.) 20 deg C, 3 h
2: 1.) isobutyl chloroformate, Et3N, 2.) NaOH / 1.) THF, -6 deg C, 20 min, 2.) water, 0 - 20 deg C, 17 h
3: 78 percent / H2, AcOH / palladium-charcoal (10percent) / 12 h
View Scheme
参考文献
Bouchaudon, Jean; Dutruc-Rosset, Gilles; Farge, Daniel; James, Claude
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 695 - 701