反应条件
1.1: lithium aluminium deuteride / diethyl ether / -78 - -45 °C / Inert atmosphere 2.1: bromine; triphenylphosphine / dichloromethane / 0.5 h / 0 - 5 °C 3.1: copper(l) iodide; potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 12 h / Inert atmosphere 4.1: benzo[1,3,2]dioxaborole / 5 h / 60 °C / Inert atmosphere 4.2: 17 h / 20 °C / Inert atmosphere; Reflux 5.1: potassium hydroxide / water / 1 h / Reflux 6.1: soybean lipoxygenase 1 / 21 - 23 °C / pH 9 / aq. buffer; Enzymatic reaction 6.2: pH 9 / aq. buffer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 3 p. 430 - 439
