反应条件
1: 12 h / 150 °C 2: 1.) nBuLi / 1.) hexane, THF, -10 deg C, 30 min, 2.) hexane, THF, RT, 16 h 3: 89 percent / pyridine / 1.5 h / 0 - 20 °C 4: 78 percent / NaN3 / dimethylformamide / 16 h / 100 °C 5: H2 / Pd/C / tetrahydrofuran; propan-1-ol / 16 h 6: 2-chloro-1-methylpyridinium iodide, n-tributylamine / CH2Cl2 / 2 h / Heating 7: 80 percent / HCO2H / 10percent Pd/C / tetrahydrofuran; propan-1-ol / 16 h / 45 °C View Scheme
参考文献
Morita; Motoki; Akimoto; Natori; Sakai; Sawa; Yamaji; Koezuka; Kobayashi; Fukushima
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2176 - 2187
