反应条件
1: 29.6 g / diethyl ether / 2 h / Ambient temperature
2: 100 percent / Br2 / CHCl3
3: 95 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / 12 h / 140 °C
4: 71 percent / LAH / diethyl ether / 4 h
5: 53 percent / KH, 1,3-diaminopropane / 3.5 h / 0 - 20 °C
6: 60 percent / CrO3, H2SO4 / acetone / 16 h / 10 °C
7: 88 percent / diethyl ether / 10 h / 0 °C
8: 1.) catecholborane, H2O, 2.) NaI, chloramine-T / 1.) 18 h, 2.) THF, H2O, 15 min
View Scheme
参考文献
Knapp, F. F.; Goodman, M. M.; Kabalka, G. W.; Sastry, K. A. R.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 94 - 97
