反应条件
1: 73 percent / 1.) Mg, 1,2-dibromoethane / tetrahydrofuran / 1.) reflux, 3.5 h; 2.) reflux, 5 h
2: 1.) p-TsOH*H2O; 2.) hydrogen / 2.) 10percent Pd-C / 1.) benzene, reflux, 2 h; 2.) cyclohexane, 40 deg C, 15 bar, 18 h
3: 74 percent / PCC / CH2Cl2 / 16 h / Ambient temperature
4: 94 percent / BuLi / tetrahydrofuran; hexane / 5 h / Ambient temperature
5: 93 percent / hydrogen / 10percent Pd-C / cyclohexane / 20 h / 40 °C / 7500.6 - 11250.9 Torr
6: 1.) p-TsOH; 2.) hydrogen / 2.) 10percent Pd-C / 1.) benzene, reflux, 5 h; 2.) cyclohexane, 40 deg C, 13 bar, 20 h
View Scheme
参考文献
Dutoit, Jean-Claude
Synthesis, 1992 , # 20 p. 982 - 984
