3-羟基-6-甲基吡啶合成路线 （共 103 条）
反应条件
1: water; NaOH-solution 2: chloroform; thionyl chloride 3: platinum; ethanol / Hydrogenation View Scheme
参考文献
Journal of the Chemical Society, , p. 560,562
反应条件
1: 75 percent / sodium hydride / dimethylformamide / 4 h / 20 °C 2: 35 percent / H2O2; acetic acid / H2O / 5 h / 100 °C 3: CH2Cl2 / 0 - 20 °C 4: 573 mg / CH2Cl2; methanol / 5 h / Heating View Scheme
参考文献
Adamczyk, Maciej; Reddy, Rajarathnam E.
Tetrahedron Asymmetry, 2001 , vol. 12, # 7 p. 1047 - 1054
反应条件
pyridine in dichloromethane T=0°C; 1.5 h;
参考文献
WYETH; CURIS, INC.
Patent: WO2008/57469 A1, 2008 ;
Location in patent: Page/Page column 238-239 ;
反应条件
1: With pyridine in dichloromethane T=0°C; 1.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
SHIONOGI and CO., LTD.
Patent: EP1422218 A1, 2004 ;
Location in patent: Page 157; 158; 225 ;
反应条件
triethylamine in dichloromethane 18 h; Ambient temperature;
参考文献
Tilley, Jefferson W.; Zawoiski, Sonja
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 386 - 390
反应条件
trifluoromethanesulfonic acid anhydride; triethylamine in tetrahydrofuran
参考文献
Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Ridgill, Mark Peter; Shaw, Duncan Edward
Patent: US2001/39286 A1, 2001 ;
反应条件
trifluoromethanesulfonic acid anhydride in dichloromethane
参考文献
Merck Frosst Canada
Patent: US5922742 A1, 1999 ;
反应条件
trifluoromethanesulfonic acid anhydride in dichloromethane
参考文献
Merck Frosst Canada, Inc.
Patent: US5202321 A1, 1993 ;
反应条件
in sodium hydroxide; dichloromethane; triethylamine
参考文献
Hoffmann-La Roche Inc.
Patent: US4916145 A1, 1990 ;
参考文献
Merck Frosst Canada, Inc.
Patent: US5314900 A1, 1994 ;
US 5314900 A
