3-羟基-6-甲基吡啶合成路线 （共 103 条）
反应条件
1: 75 percent / sodium hydride / dimethylformamide / 4 h / 20 °C 2: 35 percent / H2O2; acetic acid / H2O / 5 h / 100 °C View Scheme
参考文献
Adamczyk, Maciej; Reddy, Rajarathnam E.
Tetrahedron Asymmetry, 2001 , vol. 12, # 7 p. 1047 - 1054
反应条件
1: 94 percent / iPrNEt / CH2Cl2 2: 94 percent / m-CPBA / CHCl3 3: 75 percent / 120 °C 4: 85 percent / KOH / methanol View Scheme
参考文献
Behr, Jean-Bernard; Gourlain, Thierry; Helimi, Abdellatif; Guillerm, Georges
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1713 - 1716
反应条件
1: Br2 / pyridine / 77 h / Ambient temperature 2: 88 percent / K2CO3 / acetone / Heating 3: 77 percent / KMnO4 / H2O / 3 h / 90 °C 4: Et3N, DMAP / CH2Cl2 / 2 h / Ambient temperature 5: 98 percent / AlCl3, NaCl / 0.03 h / 150 °C View Scheme
参考文献
Kelly, T. Ross; Lang, Fengrui
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4623 - 4633
反应条件
1: Br2 / pyridine / 77 h / Ambient temperature 2: 88 percent / K2CO3 / acetone / Heating 3: 77 percent / KMnO4 / H2O / 3 h / 90 °C 4: Et3N, DMAP / CH2Cl2 / 2 h / Ambient temperature 5: 93 percent / AlCl3 / CH2Cl2 / 48 h / Heating View Scheme
参考文献
LUMIPHORE, INC.; MAGDA, Darren; XU, Jide; BUTLIN, Nathaniel, G.
Patent: WO2014/78690 A1, 2014 ;
反应条件
1: DEAD, PPh3 2: HCO2H View Scheme
参考文献
Lin, Nan-Horng; Gunn, David E.; Li, Yihong; He, Yun; Bai, Hao; Ryther, Keith B.; Kuntzweiler, Theresa; Donnelly-Roberts, Diana L.; Anderson, David J.; Campbell, Jeffrey E.; Sullivan, James P.; Arneric, Stephen P.; Holladay, Mark W.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 249 - 254
反应条件
triphenylphosphine; diethylazodicarboxylate
参考文献
Lin, Nan-Horng; Gunn, David E.; Li, Yihong; He, Yun; Bai, Hao; Ryther, Keith B.; Kuntzweiler, Theresa; Donnelly-Roberts, Diana L.; Anderson, David J.; Campbell, Jeffrey E.; Sullivan, James P.; Arneric, Stephen P.; Holladay, Mark W.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 249 - 254
反应条件
1: Br2 / pyridine / 77 h / Ambient temperature 2: 88 percent / K2CO3 / acetone / Heating 3: 77 percent / KMnO4 / H2O / 3 h / 90 °C 4: Et3N, DMAP / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
LUMIPHORE, INC.; MAGDA, Darren; XU, Jide; BUTLIN, Nathaniel, G.
Patent: WO2014/78690 A1, 2014 ;
反应条件
1.1: pyridine / dichloromethane / 1.5 h / 0 °C 2.1: piperidine; tris(4-methylphenyl)-phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere 2.2: 40 °C 2.3: 2 h / Reflux 3.1: sulfuric acid / toluene / 50 °C 4.1: potassium phosphate / palladium (II) 2,4-pentanedionate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C / Inert atmosphere View Scheme
参考文献
Tartaggia, Stefano; Caporale, Andrea; Fontana, Francesco; Stabile, Paolo; Castellin, Andrea; De Lucchi, Ottorino
RSC Advances, 2013 , vol. 3, # 40 p. 18544 - 18549
参考文献
CANON KABUSHIKI KAISHA
Patent: US2008/138656 A1, 2008 ;
反应条件
bromine in pyridine Ambient temperature;
参考文献
Mooring, Suazette Reid; Jin, Hui; Devi, Narra S.; Jabbar, Adnan A.; Kaluz, Stefan; Liu, Yuan; Van Meir, Erwin G.; Wang, Binghe
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8471 - 8489
