5-三氟甲基-3-氨基吡啶合成路线 （共 9 条）
反应条件
dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C50H70NO4PPdS; C50H70NO4PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate in 1,4-dioxane T=80°C; 24 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 15, # 14 p. 3734 - 3737
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=3102.97 Torr; 16 h;
参考文献
WO2008/79965 A1, ;
Page/Page column 72-73 ;
反应条件
hydrogenchloride in tetrahydrofuran; water T=20°C; 2 h;
参考文献
WO2014/418 A1, ;
Page/Page column 83 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=760.051 Torr; 3 h;
参考文献
WO2010/66684 A2, ;
Page/Page column 63 ;
WO 2010/066684 A2
反应条件
1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 16 h / 110 °C 2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C View Scheme
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; 0.166667 h; 2: With copper(I) bromide in water T=60°C; 1 h;
参考文献
Xue, Chu-Biao; Zheng, Changsheng; Feng, Hao; Xia, Michael; Glenn, Joseph; Cao, Ganfeng.; Metcalf, Brian W.
Patent: US2006/4018 A1, 2006 ;
Location in patent: Page/Page column 14; 36 ;
US 20060004018 A1
反应条件
1: 5-(trifluoro-methyl)pyridin-3-amine With sodium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.25 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C;
参考文献
NOVARTIS AG
Patent: WO2009/109576 A1, 2009 ;
Location in patent: Page/Page column 58 ;
WO 2009/109576 A1
反应条件
1: 5-(trifluoro-methyl)pyridin-3-amine; sodium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.25 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C;
参考文献
Burger, Matthew; Lan, Jiong; Lindvall, Mika; Nishiguchi, Gisele; Tetalman, Michelle
Patent: US2010/216839 A1, 2010 ;
Location in patent: Page/Page column 25 ;
US 20100216839 A1
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C 1.2: 20 °C / Cooling with ice 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C View Scheme
参考文献
AMGEN INC.; D'AMICO, Derin C.; HERBERICH, Bradley J.; JACKSON, Claire L.M.; PETTUS, Liping H.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan
Patent: WO2012/148775 A1, 2012 ;
WO 2012/148775 A1
