2-[(R)-(二苯基甲基)亚砜]乙酸合成路线 （共 14 条）
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in tetrachloromethane T=20°C; 48 h; Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 24 p. 2959 - 2964
反应条件
hydrogenchloride in water T=20°C;
参考文献
WO2009/90663 A1, ;
Page/Page column 9 ;
反应条件
lithium hydroxide in tetrahydrofuran; water T=0 - 20°C;
参考文献
Osorio-Lozada, Antonio; Prisinzano, Thomas; Olivo, Horacio F.
Tetrahedron Asymmetry, 2004 , vol. 15, # 23 p. 3811 - 3815
反应条件
in isopropyl alcohol T=20°C; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/103221 A2, ;
Page/Page column 20 ;
反应条件
in dimethyl sulfoxide T=90°C; 17 h; Product distribution / selectivity;
参考文献
WO2008/70143 A1, ;
Page/Page column 9 - 10 ;
反应条件
1: With (S)-1-phenyl-ethylamine in water Heating; 2: With hydrogenchloride pH=2;
参考文献
Prisinzano, Thomas; Podobinski, John; Tidgewell, Kevin; Luo, Min; Swenson, Dale
Tetrahedron Asymmetry, 2004 , vol. 15, # 6 p. 1053 - 1058
反应条件
1: 44.5 percent / 4-(dimethylamino)pyridine; 1,3-dicyclohexylcarbodiimide / CH2Cl2 2: 96 percent / lithium hydroxide / tetrahydrofuran; H2O / 0 - 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 23 p. 3811 - 3815
反应条件
1.1: 99 percent / trifluoroacetic acid / 3 h / 20 °C 2.1: 99 percent / H2SO4 / Heating 3.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C 4.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 5.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 5.2: aq. HCl / pH 2 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1.1: 99 percent / H2SO4 / Heating 2.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C 3.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 4.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 4.2: aq. HCl / pH 2 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1.1: H2SO4; 2-propanol; aq. H2O2 / methanol / 20 °C 2.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 3.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 3.2: aq. HCl / pH 2 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
