2-[(R)-(二苯基甲基)亚砜]乙酸合成路线 （共 14 条）
反应条件
1.1: 62.1 g / NaOH; H2O / ethanol / 1 h / 20 °C 2.1: (R)-(+)-α-methylbenzylamine / H2O / Heating 2.2: aq. HCl / pH 2 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 1053 - 1058
反应条件
1: With indium; pivaloyl chloride in isopropyl alcohol T=15 - 30°C; 3 h; 2: With hydrogenchloride in water; isopropyl alcohol T=20°C; 0.5 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2008/70143 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
potassium carbonate in acetone Reflux;
参考文献
Cao, Jianjing; Prisinzano, Thomas E.; Okunola, Oluyomi M.; Kopajtic, Theresa; Shook, Matthew; Katz, Jonathan L.; Newman, Amy Hauck
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 48 - 52
反应条件
hydrogenchloride in water T=20°C; 1 - 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/103221 A2, 2007 ;
Location in patent: Page/Page column 23; 25 ;
