3,5-二甲基-4-(噻吩-2-基)异噁唑合成路线 （共 3 条）
反应条件
caesium carbonate in ethanol T=110°C; 2 h;
参考文献
TARGEGEN INC.
Patent: WO2009/49028 A1, 2009 ;
Location in patent: Page/Page column 92 ;
WO 2009/049028 A1
反应条件
trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); cesium fluoride in 1,4-dioxane T=20 - 80°C; Stille-Migita cross-coupling; 24 h; Molecular sieveInert atmosphere;
参考文献
Dowlut, Meenakshi; Mallik, Debasis; Organ, Michael G.
Chemistry - A European Journal, 2010 , vol. 16, # 14 p. 4279 - 4283
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 0.25 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexanes T=-78 - 20°C; 2.25 h; 3: With hydrogenchloride in tetrahydrofuran; hexanes; water
参考文献
TARGEGEN INC.
Patent: WO2009/49028 A1, 2009 ;
Location in patent: Page/Page column 92 ;
WO 2009/049028 A1
