1: diisopropylethylamine, diethylphosphoryl cyanide / CH2Cl2 / 14 h / Ambient temperature 2: acetyl chloride, ethanedithiol / methanol / 5 h 3: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH2Cl2 / 14 h 4: trifluoroacetic acid / CH2Cl2 / 0.25 h View Scheme

1: diisopropylethylamine, diethylphosphoryl cyanide / CH2Cl2 / 14 h / Ambient temperature 2: acetyl chloride, ethanedithiol / methanol / 5 h 3: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH2Cl2 / 14 h 4: trifluoroacetic acid / CH2Cl2 / 0.25 h View Scheme

1: diisopropylethylamine, diethylphosphoryl cyanide / CH2Cl2 / 14 h / Ambient temperature 2: acetyl chloride, ethanedithiol / methanol / 5 h 3: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH2Cl2 / 14 h View Scheme

1: diisopropylethylamine, diethylphosphoryl cyanide / CH2Cl2 / 14 h / Ambient temperature 2: acetyl chloride, ethanedithiol / methanol / 5 h 3: diisopropylethylamine, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / CH2Cl2 / 14 h 4: trifluoroacetic acid / CH2Cl2 / 0.25 h View Scheme

Multi-step reaction with 3 steps 3: 98 percent / periodic acid, ruthenium trichloride hydrate / acetonitrile; CCl4; H2O / 2 h