O-叔-丁基二甲基硅烷基-N-甲基-N-t-丁氧羰基-L-酪氨酸,甲酯合成路线 （共 9 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=25°C; 48 h;
参考文献
Boger; Yohannes
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 487 - 499
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=0 - 20°C; 13 h;
参考文献
Yokokawa, Fumiaki; Inaizumi, Akiko; Shioiri, Takayuki
Tetrahedron, 2005 , vol. 61, # 6 p. 1459 - 1480
反应条件
1: 72 percent / tetrahydrofuran / 2 h / 25 °C 2: 93 percent / imidazole / dimethylformamide / 6 h / 25 °C 3: 87 percent / NaH / dimethylformamide / 48 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 3 p. 487 - 499
反应条件
1: 93 percent / imidazole / dimethylformamide / 6 h / 25 °C 2: 87 percent / NaH / dimethylformamide / 48 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 3 p. 487 - 499
反应条件
1: 95 percent / HCl (gas) / 2 h / 25 °C 2: 72 percent / tetrahydrofuran / 2 h / 25 °C 3: 93 percent / imidazole / dimethylformamide / 6 h / 25 °C 4: 87 percent / NaH / dimethylformamide / 48 h / 25 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 3 p. 487 - 499
反应条件
1: imidazole / dimethylformamide / 13 h / 0 - 20 °C 2: 3.6 g / K2CO3; H2O / tetrahydrofuran; methanol / 48 h / 20 °C 3: 84 percent / t-BuLi / tetrahydrofuran; pentane / 19 h / 0 - 20 °C 4: 94 percent / KHCO3 / dimethylformamide / 13 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 6 p. 1459 - 1480
反应条件
1: imidazole / dimethylformamide / 13 h / 0 - 20 °C 2: 3.6 g / K2CO3; H2O / tetrahydrofuran; methanol / 48 h / 20 °C 3: 84 percent / t-BuLi / tetrahydrofuran; pentane / 19 h / 0 - 20 °C 4: 94 percent / KHCO3 / dimethylformamide / 13 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 6 p. 1459 - 1480
反应条件
1: 84 percent / t-BuLi / tetrahydrofuran; pentane / 19 h / 0 - 20 °C 2: 94 percent / KHCO3 / dimethylformamide / 13 h / 0 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 6 p. 1459 - 1480
反应条件
1: 82 percent / AcOH / tetrahydrofuran; H2O / 8 h / 25 °C 2: 95 percent / LiOH / tetrahydrofuran; methanol; H2O / 1.2 h / 25 °C View Scheme
参考文献
Boger; Yohannes
Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 487 - 499
