(2-甲氧基-3-吡啶)甲醇合成路线 （共 9 条）
反应条件
1: With lithium borohydride in tetrahydrofuran T=70°C; 2 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
SYNGENTA LIMITED
Patent: WO2007/71900 A1, 2007 ;
Location in patent: Page/Page column 95 ;
反应条件
1: With sodium tetrahydroborate in ethanol T=-40°C; 0.75 h; 2: With water in ethanol T=-40 - 20°C;
参考文献
US2008/103129 A1, ;
Page/Page column 47 ;
US 20080103129 A1
反应条件
1: CHCl3; methanol 2: DIBAL-H / tetrahydrofuran; hexane / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 18 p. 3386 - 3399
反应条件
1: 1 h / Heating 2: 65 percent / methanol / 1) 20 deg C, 1 h, 2) reflux, 1 h 3: 93 percent / LiAlH4 / diethyl ether / 0.5 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 26, # 12 p. 2257 - 2272
反应条件
1: thionyl chloride / 2 h / Heating 2: 1 h / Heating 3: 65 percent / methanol / 1) 20 deg C, 1 h, 2) reflux, 1 h 4: 93 percent / LiAlH4 / diethyl ether / 0.5 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 26, # 12 p. 2257 - 2272
反应条件
1: 65 percent / methanol / 1) 20 deg C, 1 h, 2) reflux, 1 h 2: 93 percent / LiAlH4 / diethyl ether / 0.5 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 26, # 12 p. 2257 - 2272
反应条件
4-(4-(dihexadecylamino)styryl)-N-methylpyridinium iodide; EtOD; methyllithium 1.) Et2O, THF, 0 deg C, 3 h, 2.) Et2O, THF, 25 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 53, # 7 p. 1367 - 1371
反应条件
1: With thionyl chloride in dichloromethane T=20°C; 2: With sodium hydrogencarbonate in water 0.0833333 - 0.166667 h;
参考文献
Banner, Bruce Lester; Bilotta, Joseph Anthony; Fotouhi, Nader; Gillespie, Paul; Goodnow, Robert Alan; Hamilton, Matthew Michael; Haynes, Nancy-Ellen; Kowalczyk, Agnieszka; Mayweg, Alexander; Myers, Michael Paul; Pietranico-Cole, Sherrie Lynn; Scott, Nathan Robert; Thakkar, Kshitij Chhabilbhai; Tilley, Jefferson Wright
Patent: US2007/49632 A1, 2007 ;
Location in patent: Page/Page column 38-39 ;
US 20070049632 A1
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; 16 h;
参考文献
SYNGENTA LIMITED
Patent: WO2007/71900 A1, 2007 ;
Location in patent: Page/Page column 95 ;
