4-碘-2-甲基磺酰基嘧啶合成路线 （共 13 条）
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / -40 °C
1.2: 34 percent / tetrahydrofuran
2.1: 97 percent / MnO2 / CH2Cl2 / 24 h
View Scheme
参考文献
Sabat, Mark; VanRens, John C.; Laufersweiler, Matthew J.; Brugel, Todd A.; Maier, Jennifer; Golebiowski, Adam; De, Biswanath; Easwaran, Vijayasurian; Hsieh, Lily C.; Walter, Richard L.; Mekel, Marlene J.; Evdokimov, Artem; Janusz, Michael J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5973 - 5977
反应条件
1.1: isopropylmagnesium chloride / tetrahydrofuran / -40 °C
1.2: 34 percent / tetrahydrofuran
2.1: 97 percent / MnO2 / CH2Cl2 / 24 h
3.1: hydroxylamine hydrochloride; pyridine / 3 h / 95 °C
4.1: NaH / dimethylformamide / 0.5 h / 165 °C
View Scheme
参考文献
Sabat, Mark; VanRens, John C.; Laufersweiler, Matthew J.; Brugel, Todd A.; Maier, Jennifer; Golebiowski, Adam; De, Biswanath; Easwaran, Vijayasurian; Hsieh, Lily C.; Walter, Richard L.; Mekel, Marlene J.; Evdokimov, Artem; Janusz, Michael J.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5973 - 5977
反应条件
1: 68 percent / copper(I) iodide, KF, iododiazine / dimethylformamide / 10 h / 115 °C
2: 2.) iodine / 1.) THF, hexane, -100 deg C, 20 min, 2.) THF, hexane, -100 deg C, 2 h
View Scheme
参考文献
Ple, N.; Turck, A.; Heynderickx, A.; Queguiner, G.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 551 - 556
