反应条件
1.1: sodium hydroxide; hydroxylamine hydrochloride / ethanol / 2 h / 30 °C
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 15 - 20 °C
3.1: sodium methylate / methanol / 0.67 h / 0 - 25 °C
4.1: water; sodium hydroxide / tetrahydrofuran / 3 h / 20 °C
4.2: pH Ca. 3 / |Cooling with ice
View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;