N,N-二苯基-氨基甲酸 2-(乙酰氨基)-9H-嘌呤-6-基酯合成路线 （共 15 条）
反应条件
N-ethyl-N,N-diisopropylamine in pyridine 1 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 61, # 26 p. 9207 - 9212
反应条件
1.1: N,N-dimethyl-acetamide / 160 °C 2.1: diisopropylethylamine; pyridine / 4 h 2.2: 91 percent / H2O; ethanol / 3.5 h / 70 °C View Scheme
参考文献
Tetrahedron, , vol. 57, # 18 p. 4035 - 4038
反应条件
pyridine; N-ethyl-N,N-diisopropylamine
参考文献
Angewandte Chemie - International Edition, , vol. 49, # 11 p. 1963 - 1966
反应条件
1: 1,10-phenanthroline; copper diacetate / N,N-dimethyl-formamide / 72 h / 20 °C 2: lithium hydroxide hydrate; water / tetrahydrofuran / 60 °C View Scheme
参考文献
Pautus, Stephane; Sehr, Peter; Lewis, Joe; Fortune, Antoine; Wolkerstorfer, Andrea; Szolar, Oliver; Guilligay, Delphine; Lunardi, Thomas; Decout, Jean-Luc; Cusack, Stephen
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8915 - 8930
反应条件
1: 1.) BSA / 1.) DCE, 80 deg C, 15 min, 2.) toluene, room temperature, 1.5 h 2: 91 percent / aq. NH3 / methanol / 24 h / 60 °C View Scheme
参考文献
Zou; Robins
Canadian Journal of Chemistry, 1987 , vol. 65, # 6 p. 1436 - 1437
反应条件
1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH 2: 87 percent / NH4OH / methanol / 48 h / 60 °C View Scheme
参考文献
Bhan, Purshotam; Bhan, Anila; Hong, Mikung; Hartwell, John G.; Saunders, June M.; Hoke, GlennD
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1195 - 1199
反应条件
1: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) trimethylsilyl triflate / 1.) 1,2-dichloroethane, 80 deg C, 15 min, 2.) toluene, 80 deg C, 1 h 2: 75 percent / NH3 / H2O; methanol / 60 °C View Scheme
参考文献
Zou; Robins
Canadian Journal of Chemistry, 1987 , vol. 65, # 6 p. 1436 - 1437
反应条件
benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; ammonia; water 1.) DCE, 80 deg C, 15 min, 2.) toluene, 80 deg C, 2 h, 3.) room temperature, 24 h; Yield given. Multistep reaction;
参考文献
Robins, Morris J.; Zou, Ruiming; Guo, Zhiqiang; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9207 - 9212
反应条件
1.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 0.25 h / 80 °C / Inert atmosphere; Sealed tube 1.2: 1 h / 80 °C / Inert atmosphere 2.1: ammonium hydroxide; water / methanol / 24 h / 70 °C / Sealed tube View Scheme
参考文献
Koszytkowska-Stawinska, Mariola
Nucleosides, Nucleotides and Nucleic Acids, 2010 , vol. 29, # 10 p. 768 - 785
反应条件
1.1: 43 percent / DBU / dimethylformamide / 84 h / 20 °C 2.1: LiBH4 / ethanol / 7 h / 20 °C 2.2: 52 percent / NH3 / methanol / 12 h / 20 °C View Scheme
参考文献
Guillarme, Stephane; Legoupy, Stephanie; Aubertin, Anne-Marie; Olicard, Cecile; Bourgougnon, Nathalie; Huet, Francois
Tetrahedron, 2003 , vol. 59, # 12 p. 2177 - 2184
