N,N-二苯基-氨基甲酸 2-(乙酰氨基)-9H-嘌呤-6-基酯合成路线 （共 15 条）
反应条件
in 1,2-dichloro-ethane T=80°C; 0.25 h;
参考文献
Soerensen, Mads D.; Kvaernoe, Lisbet; Bryld, Torsten; Hakansson, Anders E.; Verbeure, Birgit; Gaubert, Gilles; Herdewijn, Piet; Wengel, Jesper
Journal of the American Chemical Society, 2002 , vol. 124, # 10 p. 2164 - 2176
反应条件
sulfuric acid; mercury(II) diacetate; hydroquinone in ethyl acetate; N,N-dimethyl-formamide 6 h; Heating;
参考文献
Dalpozzo, Renato; De Nino, Antonio; Maiuolo, Loredana; Procopio, Antonio; De Munno, Giovanni; Sindona, Giovanni
Tetrahedron, 2001 , vol. 57, # 18 p. 4035 - 4038
反应条件
1: 1.) BSA, 2.) TMSOTf / 1.) DCE, 80 deg C, 15 min, 2.) toluene, 80 deg C, 1 h 2: 84 percent / aq. NH3 / methanol / 24 h / 60 °C View Scheme
参考文献
Robins, Morris J.; Zou, Ruiming; Guo, Zhiqiang; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9207 - 9212
反应条件
1.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / 50 - 60 °C 1.2: 74 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 4 h / 65 - 70 °C 2.1: 78 percent / hydrazine hydrate; acetic acid; pyridine / 24 h / 20 °C 3.1: 81 percent / pyridine / CH2Cl2 / -40 °C 4.1: TBAF / tetrahydrofuran / 0.75 h / 20 °C View Scheme
参考文献
Gadthula, Srinivas; Chu, Chung K.; Schinazi, Raymond F.
Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 10-12 p. 1707 - 1727
反应条件
1: 1.) BSA, TMSOTf / 1.) DCE, 2.) TolH
2: 87 percent / NH4OH / methanol / 48 h / 60 °C
3: 92 percent / methanol
View Scheme
参考文献
Bhan, Purshotam; Bhan, Anila; Hong, Mikung; Hartwell, John G.; Saunders, June M.; Hoke, GlennD
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1195 - 1199
