1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: With ammonia in water; N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2012/13643 A1, 2012 ;
Location in patent: Page/Page column 48 ;