1,4-二氮杂环庚烷-1-甲酸叔丁酯合成路线 （共 25 条）
反应条件
in acetic acid T=20°C; 24 h;
参考文献
World-Trade Import-Export Wtie, AG; GARCÍA ARMENTA, María Elena; ALVAREZ OCHOA, Víctor Guillermo; OSNAYA MORALES, Roberto Carlos; ZARATE BARAJAS, Erika Alejandra
Patent: EP2578588 A1, 2013 ;
Location in patent: Paragraph 0110; 0111 ;
反应条件
triethylamine in dichloromethane
反应条件
in methanol; ethyl acetate
参考文献
Gyogyszerkutato Intezet KFT
Patent: US5380724 A1, 1995 ;
参考文献
WO2003/101994 A1, ;
Page 84 ;
WO 03/101994 A1
反应条件
in methanol; ethyl acetate
反应条件
di-tert-butyl dicarbonate T=50°C;
参考文献
US6337326 B1, ;
Page column 6 ;
US 6337326 B1
反应条件
1: in dichloromethane T=25°C; 2 h; 2: With trifluoroacetic acid in methanol; ethyl acetate T=20°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: US2008/153812 A1, 2008 ;
Location in patent: Page/Page column 154 ;
US 20080153812 A1
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride / 1,4-dioxane / 12 h / 20 °C / |Inert atmosphere 2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C View Scheme
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
反应条件
1: 13 percent / tetrakis(triphenylphosphine)palladium(0); potassium tert-butoxide / toluene / 4 h / 80 °C 2: 85 percent / trifluoroacetic acid / CH2Cl2 / 6 h 3: 39 percent / N-bromosuccinimide / acetonitrile / 0.25 h View Scheme
参考文献
Nielsen, Simon Feldbk; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Liljefors, Tommy; Peters, Dan
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2217 - 2226
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine / tert-butyl alcohol; 1,4-dioxane / 2 h / |Inert atmosphere; |Reflux 2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C View Scheme
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
