1,4-二氮杂环庚烷-1-甲酸叔丁酯合成路线 （共 25 条）
反应条件
1: copper(l) iodide; potassium phosphate / isopropyl alcohol / 10 h / 80 °C / |Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C
View Scheme
参考文献
Saito, Keiji; Nakao, Akira; Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Oizumi, Kiyoshi; Yano, Kazuki; Ohata, Keiko; Nakai, Daisuke; Nagai, Yoko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1628 - 1642
反应条件
1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With sodium hydroxide
Reflux;
2: With NH2NH2•xH2O
3: N-(tert-butyl-oxycarbonyl)-homopiperazine
参考文献
THE JOHNS HOPKINS UNIVERSITY; KERN, Scott; GHOSH, Soma
Patent: WO2014/78633 A1, 2014 ;
Location in patent: Paragraph 0078 ;
反应条件
1: Hunigs base / N,N-dimethyl-acetamide
2: HCl / ethanol
View Scheme
参考文献
Cockcroft, Xiao-Ling; Dillon, Krystyna J.; Dixon, Lesley; Drzewiecki, Jan; Kerrigan, Frank; Loh Jr., Vincent M.; Martin, Niall M.B.; Menear, Keith A.; Smith, Graeme C.M.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 1040 - 1044
反应条件
1: potassium carbonate / N,N-dimethyl-formamide
2: trifluoroacetic acid
View Scheme
参考文献
VIFOR (INTERNATIONAL) AG
Patent: US2012/214798 A1, 2012 ;
反应条件
1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating
2: H2 / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr
View Scheme
参考文献
Koshio, Hiroyuki; Hirayama, Fukushi; Ishihara, Tsukasa; Taniuchi, Yuta; Sato, Kazuo; Sakai-Moritani, Yumiko; Kaku, Seiji; Kawasaki, Tomihisa; Matsumoto, Yuzo; Sakamoto, Shuichi; Tsukamoto, Shin-Ichi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2179 - 2191
