4-溴-2,5-二氟苯胺合成路线 （共 10 条）
反应条件
bromine in dichloromethane; water; acetic acid
反应条件
bromine in acetic acid
反应条件
hydrogenchloride in methanol
参考文献
US6235740 B1, ;
US 6235740 B1
反应条件
CuCN in water; N,N-dimethyl-formamide
参考文献
AMERICAN CYANAMID COMPANY
Patent: EP224001 B1, 1991 ;
反应条件
CuCN in N,N-dimethyl-formamide
参考文献
American Cyanamid Company
Patent: US4863959 A1, 1989 ;
反应条件
1: copper (I) cyanide; 4-Bromo-2,5-difluorobenzenamine in N,N-dimethyl-formamide Heating / reflux; 2: sodium cyanide in water; N,N-dimethyl-formamide 0.5 h;
参考文献
PFIZER INC.
Patent: WO2009/69044 A1, 2009 ;
Location in patent: Page/Page column 90 ;
WO 2009/069044 A1
反应条件
1: With hydrogenchloride; sodium nitrite 2: With potassium iodide
参考文献
Hird, Michael; Toyne, Kenneth J.; Goodby, John W.; Gray, George W.; Minter, Victoria; Tuffin, Rachel P.; McDonnell, Damien G.
Journal of Materials Chemistry, 2004 , vol. 14, # 11 p. 1731 - 1743
反应条件
copper(l) iodide; N,N-dimethylethylenediamine; sodium iodide in 1,4-dioxane
T=140°C; 3 h; Inert atmosphere;
参考文献
Wellenzohn, Bernd; Lessel, Uta; Beller, Andreas; Isambert, Timo; Hoenke, Christoph; Nosse, Bernd
Journal of Medicinal Chemistry, 2012 , vol. 55, # 24 p. 11031 - 11041
反应条件
1: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran
0.166667 h;
2: With tri-tert-butyl phosphine in tetrahydrofuran; hexanes
T=25°C; 16 h;
参考文献
Wyeth
Patent: US2007/27201 A1, 2007 ;
Location in patent: Page/Page column 19 ;
US 20070027201 A1
