4-氨基-3-溴-2,5-二氟苯甲腈合成路线 （共 3 条）
反应条件
bromine in dichloromethane; water; acetic acid
参考文献
AMERICAN CYANAMID COMPANY
Patent: EP224001 B1, 1991 ;
反应条件
bromine in acetic acid
参考文献
American Cyanamid Company
Patent: US4863959 A1, 1989 ;
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 h / -78 - 20 °C 2: hypophosphorous acid; sodium nitrite / water; acetic acid / 0 - 20 °C 3: methanol; sodium tetrahydroborate / 0.17 h / 20 °C View Scheme
参考文献
CELLZOME LIMITED; OXENFORD, Sally; HOBSON, Andrew; OLIVER, Kathryn; RATCLIFFE, Andrew; RAMSDEN, Nigel
Patent: WO2013/17479 A1, 2013 ;
WO 2013/017479 A1
