1: With lithium hydroxide; water in tetrahydrofuran; methanol T=22°C; 24 h; Inert atmosphere; 2: With water; citric acid in tetrahydrofuran; methanol T=0°C; Inert atmosphere;

Multi-step reaction with 3 steps 1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2.5 h / 20 °C / Inert atmosphere2.1: pyridine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere3.2: 15.75 h / 0 - 20 °C / Inert atmosphere  

Multi-step reaction with 2 steps 1.1: pyridine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere2.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere2.2: 15.75 h / 0 - 20 °C / Inert atmosphere