3,5-二氟-4-硝基苯甲腈合成路线 （共 3 条）
反应条件
1-methyl-pyrrolidin-2-one
T=160 - 165°C; 6 h; Inert atmosphere;
参考文献
Rueeger, Heinrich; Lueoend, Rainer; Rogel, Olivier; Rondeau, Jean-Michel; Moebitz, Henrik; MacHauer, Rainer; Jacobson, Laura; Staufenbiel, Matthias; Desrayaud, Sandrine; Neumann, Ulf
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3364 - 3386
反应条件
1: sodium perborate; acetic acid / 21 h / 65 - 70 °C / Inert atmosphere
2: 1-methyl-pyrrolidin-2-one / 6 h / 160 - 165 °C / Inert atmosphere
View Scheme
参考文献
Rueeger, Heinrich; Lueoend, Rainer; Rogel, Olivier; Rondeau, Jean-Michel; Moebitz, Henrik; MacHauer, Rainer; Jacobson, Laura; Staufenbiel, Matthias; Desrayaud, Sandrine; Neumann, Ulf
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3364 - 3386
反应条件
1.1: thionyl chloride / 0 - 25 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / 0 - 5 °C / Inert atmosphere
2.2: 0.5 h / 25 °C / Cooling with ice; Inert atmosphere
View Scheme
参考文献
Rueeger, Heinrich; Lueoend, Rainer; Rogel, Olivier; Rondeau, Jean-Michel; Moebitz, Henrik; MacHauer, Rainer; Jacobson, Laura; Staufenbiel, Matthias; Desrayaud, Sandrine; Neumann, Ulf
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3364 - 3386
