呋喃[2,3-C]并吡啶-2-甲醛合成路线 （共 7 条）
反应条件
in formic acid; water
参考文献
Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Groppi JR., Vincent E.
Patent: US2003/45540 A1, 2003 ;
反应条件
1: furolt;2,3-cgt;pyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: formic acid ethyl ester in tetrahydrofuran
参考文献
Lu, Zhijian; Bohn, Joann; Rano, Tom; Rutkowski, Carrie A.; Simcoe, Amy L.; Olsen, David B.; Schleif, William A.; Carella, Anthony; Gabryelski, Lori; Jin, Lixia; Lin, Jiunn H.; Emini, Emilio; Chapman, Kevin; Tata, James R.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 23 p. 5311 - 5314
反应条件
Yield given. Multistep reaction;
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
1: AcOH / ethanol / Ambient temperature 2: NaCNBH3 / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
potassium dihydrogenphosphate; NaClO2 in tetrahydrofuran; water; tert-butyl alcohol
参考文献
Wishka, Donn G.; Reitz, Steven Charles; Piotrowski, David W.; Groppi JR., Vincent E.
Patent: US2003/45540 A1, 2003 ;
反应条件
1: 98 percent / hydroxylamine hydrochloride, K2CO3 / aq. ethanol / 2 h / Ambient temperature
2: 73 percent / p-toluenesulfonic acid, acetic anhydride / 5 h / Heating
3: 95 percent / KOH / aq. ethanol / 2 h / Heating
View Scheme
参考文献
Morita, Hiroyuki; Shiotani, Shunsaku
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 373 - 376
反应条件
potassium hydroxide; hydrazine hydrate in ethanol
1 h; Heating;
参考文献
Morita, Hiroyuki; Shiotani, Shunsaku
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 373 - 376
