4-硝基吡啶-N-氧化物合成路线 （共 92 条）
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C 1.2: 15 h / 100 °C 2.1: p-toluenesulfonyl chloride / dichloromethane / 1.67 h / 0 - 20 °C 3.1: trifluoroacetic acid / dichloromethane / 48 h / |Reflux View Scheme
参考文献
Ichihara, Yoshinori; Fujimura, Ryohei; Tsuneki, Hiroshi; Wada, Tsutomu; Okamoto, Kentaro; Gouda, Hiroaki; Hirono, Shuichi; Sugimoto, Kenji; Matsuya, Yuji; Sasaoka, Toshiyasu; Toyooka, Naoki
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 649 - 660
反应条件
1: sulfuryl chloride / 110 °C 2: aqueous NH3 / 180 °C 3: ethanolic sodium ethylate / 160 °C View Scheme
参考文献
Kolder; den Hertog
Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 285,291
反应条件
1: 2 h / 65 - 70 °C 2: 73 percent / H2O / -8 - -7 °C 3: 1.) 90percent H2SO4, 2.) NaNO2 / 1.) 120 deg C, 2 h, 2.) water, 20-25 deg C, 1 h, then 80 deg C, 1 h 4: 90 percent / Na / 2 h / Heating View Scheme
参考文献
Hayashi, Masashi; Shiomi, Noriyuki; Funahashi, Yasuhiro; Nakamura, Shuichi
Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19366 - 19369
反应条件
1: 75 percent / methanol View Scheme
参考文献
Walters, Michael A.; Shay, John J.
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7575 - 7578
反应条件
chloroform; phosphorus oxytribromide
参考文献
Hamana et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1337,1340
Chem.Abstr., 1957 , p. 6639
反应条件
chloroform; phosphorus trichoride Behandeln der kalten Reaktionsloesung mit Acetylchlorid;
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 247
反应条件
Behandeln der Reaktionsloesung mit Acetylchlorid;
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 247
反应条件
1: chloroform; phosphorus (III)-chloride / Behandeln der kalten Reaktionsloesung mit Acetylchlorid 2: aqueous Na2SO3 View Scheme
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 247
反应条件
1: CH3COCl 2: H2O / 18 h / 140 °C View Scheme
参考文献
Uno, Bunji; Kano, Kenji; Kaida, Naoki; Kubota, Tanekazu
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1989 , vol. 45, # 9 p. 937 - 944
反应条件
potassium hydroxide; nickel monoaluminide 19 h; Heating;
参考文献
Lunn, George; Sansone, Eric B.
Journal of Organic Chemistry, 1986 , vol. 51, # 4 p. 513 - 517
