4-硝基吡啶-N-氧化物合成路线 （共 92 条）
反应条件
1: 75 percent / methanol 2: 79 percent / POCl3 / 16 h / 95 °C View Scheme
参考文献
Walters, Michael A.; Shay, John J.
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7575 - 7578
反应条件
1: 20 percent / 1,2-dichloro-ethane / 12 h / Heating 2: 90 percent / CHCl3 / 4 h / Heating 3: 95 percent / conc. HCl / 8 h / Heating View Scheme
参考文献
Kolder; den Hertog
Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 285,291
参考文献
Shiseido Company, Ltd.
Patent: US5219847 A1, 1993 ;
反应条件
1: 4-nitro-pyridine N-oxide With dimethyl sulfate in water T=-8 - 70°C; 2 h; Inert atmosphere; 2: potassium cyanide in water 12 h; Inert atmosphere;
参考文献
Hayashi, Masashi; Shiomi, Noriyuki; Funahashi, Yasuhiro; Nakamura, Shuichi
Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19366 - 19369
反应条件
1: 2 h / 65 - 70 °C 2: 73 percent / H2O / -8 - -7 °C View Scheme
参考文献
Desjardins, Sylvie Y.; Cavell, Kingsley J.; Hoare, Jason L.; Skelton, Brian W.; Sobolev, Alexander N.; White, Allan H.; Keim, Wilhelm
Journal of Organometallic Chemistry, 1997 , vol. 544, # 2 p. 163 - 174
反应条件
1: benzyl alcohol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; 2: 4-nitro-pyridine N-oxide in N,N-dimethyl-formamide T=100°C; 15 h;
参考文献
Ichihara, Yoshinori; Fujimura, Ryohei; Tsuneki, Hiroshi; Wada, Tsutomu; Okamoto, Kentaro; Gouda, Hiroaki; Hirono, Shuichi; Sugimoto, Kenji; Matsuya, Yuji; Sasaoka, Toshiyasu; Toyooka, Naoki
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 649 - 660
参考文献
Ochiai
Journal of Organic Chemistry, 1953 , vol. 18, p. 534,541
Full Text Show Details
Ochiai; Teshigawara
Yakugaku Zasshi, 1945 , vol. 65, # 4/8 p. 435,439
Chem.Abstr., 1951 , p. 8527
反应条件
chloroformic acid ethyl ester in 1,2-dichloro-ethane T=40 - 65°C;
参考文献
Veerareddy, Arava; Surendrareddy, Gogireddy; Dubey
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 4 p. 961 - 964
参考文献
Walters, Michael A.; Shay, John J.
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7575 - 7578
反应条件
1: With trichlorophosphate 10 h; Heating / reflux; 2: With water 3: With sodium hydroxide in water pH=~ 5;
参考文献
BIONOMICS LIMITED
Patent: WO2008/70908 A1, 2008 ;
Location in patent: Page/Page column 74 ;
