1: 91.6 percent / HCl / ethyl acetate / Ambient temperature 3: 1.) NaH / 1.) DMF, room temp., 1 h; 2.) reflux, 2 h 4: 70.4 percent / KO-t-Bu / H2O; diethyl ether / 240 h 5: thionyl chloride / 2 h / Heating View Scheme

1: 1.) NaH / 1.) DMF, room temp., 1 h; 2.) reflux, 2 h 2: 70.4 percent / KO-t-Bu / H2O; diethyl ether / 240 h 3: thionyl chloride / 2 h / Heating View Scheme

1: 1.) n-BuLi, TMEDA / 1.) hexane, 0 - 4 deg C, 1 h; 2.) 1 h 2: 57.4 percent / HCl, p-toluenesulfonic acid / methanol / Ambient temperature 3: 1.) NaH / 1.) DMF, room temp., 1 h; 2.) reflux, 2 h 4: 70.4 percent / KO-t-Bu / H2O; diethyl ether / 240 h 5: thionyl chloride / 2 h / Heating View Scheme

2: 1.) NaH / 1.) DMF, room temp., 1 h; 2.) reflux, 2 h 3: 70.4 percent / KO-t-Bu / H2O; diethyl ether / 240 h 4: thionyl chloride / 2 h / Heating View Scheme

1: 70.4 percent / KO-t-Bu / H2O; diethyl ether / 240 h 2: thionyl chloride / 2 h / Heating View Scheme

thionyl chloride 2 h; Heating;