1: With boron trifluoride diethyl etherate in methanol; toluene T=-5°C; 155 h; 2: With sodium hydrogencarbonate in water; toluene optical yield given as percent eeenantioselective reaction;

1: With boron trifluoride diethyl etherate in methanol; toluene T=-5°C; 155 h; 2: With sodium hydrogencarbonate in water; toluene optical yield given as percent eeenantioselective reaction;

1: triethylamine / toluene / 2.25 h / 0 - 20 °C 2: boron trifluoride diethyl etherate / methanol; toluene / 155 h / -5 °C View Scheme

1: oxalyl dichloride / toluene / 3.17 h / 0 - 20 °C 2: triethylamine / toluene / 2.25 h / 0 - 20 °C 3: boron trifluoride diethyl etherate / methanol; toluene / 155 h / -5 °C View Scheme