2-氯-4-(4-甲基哌嗪-1-基)苯胺合成路线 （共 4 条）
反应条件
1: With iron; acetic acid T=17 - 75°C; 2 h; 2: With diatomaceous earth in methanol; dichloromethane pH=12;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/24824 A1, 2009 ;
Location in patent: Page/Page column 87 ;
WO 2009/024824 A1
反应条件
1: 60 °C 2: sulfuric acid; copper(l) chloride; sodium nitrite 3: iron; acetic acid / tetrahydrofuran View Scheme
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Breslin, Henry J.; Gingrich, Diane E.; Huang, Zeqi; Lisko, Joseph G.; Mason, Jennifer L.; Milkiewicz, Karen L.; Thieu, Tho V.; Underiner, Ted L.; Wells, Gregory J.; Wells-Knecht, Kevin J.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7325 - 7330
反应条件
1: 60 °C 2: sulfuric acid; copper(l) chloride; sodium nitrite 3: iron; acetic acid / tetrahydrofuran View Scheme
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Breslin, Henry J.; Gingrich, Diane E.; Huang, Zeqi; Lisko, Joseph G.; Mason, Jennifer L.; Milkiewicz, Karen L.; Thieu, Tho V.; Underiner, Ted L.; Wells, Gregory J.; Wells-Knecht, Kevin J.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7325 - 7330
反应条件
1: sulfuric acid; copper(l) chloride; sodium nitrite 2: iron; acetic acid / tetrahydrofuran View Scheme
参考文献
Weinberg, Linda R.; Albom, Mark S.; Angeles, Thelma S.; Breslin, Henry J.; Gingrich, Diane E.; Huang, Zeqi; Lisko, Joseph G.; Mason, Jennifer L.; Milkiewicz, Karen L.; Thieu, Tho V.; Underiner, Ted L.; Wells, Gregory J.; Wells-Knecht, Kevin J.; Dorsey, Bruce D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7325 - 7330
