1-吡咯烷-1-环己烯合成路线 （共 146 条）
反应条件
1: in tetrahydrofuran
T=-35 - 0°C; 2.5 h; Inert atmosphere;
2: With ammonia in tetrahydrofuran; methanol
T=20°C; 18 h;
参考文献
Katholieke Universiteit Leuven; Chaltin, Patrick; Christ, Frauke; Debyser, Zeger; De Maeyer, Marc; Marchand, Arnaud; Marchand, Damien; Voet, Arnout
Patent: US2013/245049 A1, 2013 ;
Location in patent: Paragraph 0458 ;
反应条件
1: 2) H2O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h
2: 55.2 percent / Ac2O, azeotropic HBr in H2O / 4 h / 140 °C
3: 90.5 percent / p-TsOH / benzene / 6 h / Heating; azeotropic dist.
View Scheme
参考文献
Wimmer; Romanuk
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 10 p. 2573 - 2586
反应条件
in chloroform
T=0 - 45°C; Diels-Alder reaction; 0.583333 h; regioselective reaction;
参考文献
Anderson, Erin D.; Boger, Dale L.
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 12285 - 12292
反应条件
hydrogenchloride; triethylamine
1.) acetonitrile, 14 h, reflux, 2.) 1 h, room temperature; Yield given. Multistep reaction;
参考文献
Scholz, Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 655 - 658
反应条件
1: H2O / reflux, dioxane, 12 h
2: 100 percent / NaBH4 / tetrahydrofuran
3: 99 percent / CH2Cl2 / 20 h / Heating
View Scheme
参考文献
Clive, Derrick L. J.; Beaulieu, Pierre L.; Set, Lu
Journal of Organic Chemistry, 1984 , vol. 49, p. 1313 - 1314
反应条件
1: (i) , (ii) aq. HCl
2: <PhCH2NMe3>OH / methanol
3: aq. HCl / acetic acid / Heating
View Scheme
参考文献
Fusco,R. et al.
Farmaco, Edizione Scientifica, 1965 , vol. 20, p. 393 - 407
反应条件
1: (i), (ii) aq. HCl
2: <PhCH2NMe3>OH / methanol
3: aq. HCl / acetic acid / Heating
View Scheme
参考文献
Fusco,R. et al.
Farmaco, Edizione Scientifica, 1965 , vol. 20, p. 393 - 407
反应条件
1: 25 °C
2: liquid NH3, NH4OAc
View Scheme
参考文献
Law, Kam Wah; Lai, Ting-Fong; Sammes, Michael P.; Katritzky, Alan R.; Mak, Thomas C.W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 111 - 118
反应条件
1: (i), (ii) aq. HCl
2: <PhCH2NMe3>OH / methanol
3: aq. HCl / acetic acid / Heating
View Scheme
参考文献
Fusco,R. et al.
Farmaco, Edizione Scientifica, 1965 , vol. 20, p. 393 - 407
反应条件
1: 25 °C
2: HCl / methanol / 0 °C
View Scheme
参考文献
Law, Kam Wah; Lai, Ting-Fong; Sammes, Michael P.; Katritzky, Alan R.; Mak, Thomas C.W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 111 - 118
