1-吡咯烷-1-环己烯合成路线 （共 146 条）
反应条件
1: H2O / reflux, dioxane, 12 h
2: 100 percent / NaBH4 / tetrahydrofuran
3: 99 percent / CH2Cl2 / 20 h / Heating
4: 1.) Ph3SnH, azo-bis(isobutyronitrile), 2.) 80percent AcOH-H2O / 1.) reflux, benzene, 20 h, 2.) 1 h
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参考文献
Clive, Derrick L. J.; Beaulieu, Pierre L.; Set, Lu
Journal of Organic Chemistry, 1984 , vol. 49, p. 1313 - 1314
反应条件
(i) Et3N, (ii) aq. HCl; Multistep reaction;
参考文献
Kuehne,M.E.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2124 - 2128
反应条件
1.1: NaI / acetone; acetonitrile / 24 h / Heating
1.2: 68 percent / H2O / 2 h / Heating
2.1: O3 / CH2Cl2 / -70 °C
2.2: 85 percent / Me2S / CH2Cl2; methanol / 5 h / 20 °C
3.1: 92 percent / aq. KOH / ethanol / 6 h / Heating
View Scheme
参考文献
Stanetty, Peter; Bahardoust, M. Hassan; Mihovilovic, Marko D.; Mereiter, Kurt
Monatshefte fur Chemie, 1999 , vol. 130, # 10 p. 1257 - 1268
反应条件
1.1: 1,4-dioxane / 3 h / Reflux
1.2: 1 h / Reflux
2.1: 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 0.5 h / 0 °C
2.2: 7 h
2.3: 15.5 h / -18 - 20 °C
3.1: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 3 h / 120 °C
View Scheme
参考文献
Amat, Mercedes; Navio, Laura; Llor, Nuria; Molins, Elies; Bosch, Joan
Organic Letters, 2012 , vol. 14, # 1 p. 210 - 213
反应条件
(i) dioxane, (ii) NaOAc, aq. AcOH, (iii) (cyclization); Multistep reaction;
参考文献
Stork,G. et al.
Journal of the American Chemical Society, 1963 , vol. 85, p. 207 - 222
反应条件
methanol; sulfuric acid; water
参考文献
Stork
Patent: US2773099 , 1954 ;
Full Text Show Details
Stork et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 2029
