1-吡咯烷-1-环己烯合成路线 （共 146 条）
反应条件
1: 50 percent / triethylamine / benzene / 7 h / Heating 2: 1.) LiAlH4; 2.) H2O, 30percent NaOH / 1.) ether, room temperature, 3 h; 2.) 0 deg C, 15 min 3: 92 percent / oxalic acid / dioxane / 10 h / Heating View Scheme
参考文献
Carlsson, S.; El-Barbary, A. A.; Lawesson, S.-O.
Bulletin des Societes Chimiques Belges, 1980 , vol. 89, # 8 p. 643 - 650
反应条件
triethylamine in benzene T=25°C;
参考文献
El-Barbary, A. A.; Carlsson, S.; Lawesson, S.-O.
Tetrahedron, 1982 , vol. 38, # 3 p. 405 - 412
反应条件
1: in acetonitrile T=20°C; 3 h; 2: With water in acetonitrile Kinetics; Concentration;
参考文献
Chemistry - An Asian Journal, , vol. 7, # 6 p. 1401 - 1407
反应条件
1: With sodium iodide in 1-methyl-pyrrolidin-2-one T=20°C; 11 h; 2: With water in 1-methyl-pyrrolidin-2-one 11 h; Product distribution / selectivity;
参考文献
GENKYO TEX
Patent: WO2008/116926 A1, 2008 ;
Location in patent: Page/Page column 48; 49 ;
WO 2008/116926 A1
反应条件
1: (i), (ii) H2O 2: CrO3, H2SO4 / acetone / (oxidation) View Scheme
参考文献
Britten,A.Z. et al.
Tetrahedron, 1969 , vol. 25, p. 3157 - 3160
反应条件
in chloroform T=20 - 60°C; Diels-Alder reaction; 14 h; regioselective reaction;
参考文献
Anderson, Erin D.; Boger, Dale L.
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 12285 - 12292
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gingrich, Henry L.; Huang, Qiurong; Morales, Angel L.; Jones, Maitland
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3803 - 3806
反应条件
1,4-dioxane anschliessend Behandeln mit DMF und Erhitzen des hierbei erhaltenen Reaktionsgemisches mit H2O;
参考文献
Stork
Patent: US2773099 , 1954 ;
Full Text Show Details
Stork et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 2029
反应条件
1: 64 percent / ethanol / 16 h 2: 100 percent / LiAlH4 / diethyl ether / 3 h / Ambient temperature 3: 93 percent / oxalic acid / dioxane / 6 h / Heating View Scheme
参考文献
Carlsson, S.; Lawesson, S.-O.
Tetrahedron, 1980 , vol. 36, p. 3585 - 3590
反应条件
1: 2) H2O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h 2: 31.2 percent / LiAlH4 / diethyl ether / 4 h / Ambient temperature 3: 1) 85percent H3PO4, 2) H2 / 2) Pd/CaCO3 / 1) 100 deg C, 4 h, 2) hexane, 12 h View Scheme
参考文献
Rejzek; Wimmer; Saman; Ricankova; Nemec
Helvetica Chimica Acta, 1994 , vol. 77, # 5 p. 1241 - 1255
